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Predictive factors for ovarian recovery include younger age at first chemotherapy administration and absence of concomitant radiotherapy (91)

Predictive factors for ovarian recovery include younger age at first chemotherapy administration and absence of concomitant radiotherapy (91)

Ovarian or egg cryopreservation and transplantation of the thawed tissue are not yet clinically established; however there is no contraindication for cryopreservation combined with GnRH agonist administration (101).

Some studies have reported the spontaneous return of ovarian function after several years in women with chemotherapy- or radiotherapy-induced ovarian failure (106, 107). The exact mechanism is unknown; however, it is theoretically possible that the constant stimulation of ovaries by postmenopausal levels of gonadotropins ent. Successful pregnancies have been reported among women who had return of ovarian function. There is an increase in miscarriage, small for gestational age offspring, and reduction in live births in women treated with chemotherapy (108).

Although no prospective studies of ovarian function and gonadotropin levels before and after pelvic-adnexal surgeries have been done, these procedures have the potential to damage the ovary by affecting its blood supply or causing inflammation in the pelvic area (109,110).

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